Preheat oven to 350°F. Spray 9x13-inch baking dish with non-stick spray.
Brown ground beef and diced onion in large skillet over medium-high heat, 7-8 minutes.
Drain excess fat, leaving about 1 tablespoon.
Stir in sloppy joe sauce, Worcestershire sauce, garlic powder, salt, and pepper. Add pickle relish if using. Simmer 3-4 minutes.
Cut each biscuit into 6 pieces using sharp knife or pizza cutter.
Remove skillet from heat. Add biscuit pieces and 1½ cups cheese. Gently fold until combined.
Spread mixture evenly in prepared baking dish.
Sprinkle remaining ½ cup cheese on top.
Bake 28-30 minutes until biscuits are golden brown and cooked through.
Let rest 5 minutes before serving.